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Characterizing Sleep Problems in 16p11.2 Deletion and Duplication
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- Author(s): Kamara, Dana (ORCID
Kamara, Dana (ORCID 0000-0003-2743-1591 ); De Boeck, Paul; Lecavalier, Luc; Neuhaus, Emily; Beauchaine, Theodore P.- Language:
English- Source:
Journal of Autism and Developmental Disorders. Apr 2023 53(4):1462-1475.- Publication Date:
2023- Document Type:
Journal Articles
Reports - Research - Language:
- Additional Information
- Availability: Springer. Available from: Springer Nature. One New York Plaza, Suite 4600, New York, NY 10004. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-460-1700; e-mail: [email protected]; Web site: https://link.springer.com/
- Peer Reviewed: Y
- Source: 14
- Sponsoring Agency: National Institutes of Health (NIH) (DHHS)
- Contract Number: UH2DE025980
UL1TR002733 - Subject Terms:
- Accession Number: 10.1007/s10803-021-05311-2
- ISSN: 0162-3257
1573-3432 - Abstract: Studies of 16p11.2 copy number variants (CNVs) provide an avenue to identify mechanisms of impairment and develop targeted treatments for individuals with neurodevelopmental disorders. 16p11.2 deletion and duplication phenotypes are currently being ascertained; however, sleep disturbances are minimally described. In this study, we examine sleep disturbance in a well-characterized national sample of 16p11.2 CNVs, the Simons Foundation Autism Research Initiative (SFARI) database of youth and adults (n = 692). Factor analyses and multilevel models of derived sleep questionnaires for youth (n = 345) and adults (n = 347) indicate that 16p11.2 carriers show elevated sleep disturbance relative to community controls. Non-carrier family members also show elevated sleep disturbance. However, sleep duration does not differ between carriers and controls. Further studies of sleep in 16p11.2 are needed.
- Abstract: As Provided
- Publication Date: 2023
- Accession Number: EJ1372082
- Availability:
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