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Wando Mount Pleasant Library
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St. Paul's/Hollywood Library
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How Robust Is the Evidence for a Role of Oxidative Stress in Autism Spectrum Disorders and Intellectual Disabilities?
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- Author(s): Burke, Shanna L. (ORCID
Burke, Shanna L. (ORCID 0000-0001-6969-3536 ); Cobb, Jessica; Agarwal, Rumi; Maddux, Marlaina; Cooke, Marcus S.- Language:
English- Source:
Journal of Autism and Developmental Disorders. May 2021 51(5):1428-1445.- Publication Date:
2021- Document Type:
Journal Articles
Information Analyses - Language:
- Additional Information
- Availability: Springer. Available from: Springer Nature. One New York Plaza, Suite 4600, New York, NY 10004. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-460-1700; e-mail: [email protected]; Web site: https://link.springer.com/
- Peer Reviewed: Y
- Source: 18
- Subject Terms:
- Accession Number: 10.1007/s10803-020-04611-3
- ISSN: 0162-3257
- Abstract: Growing interest in the pathogenesis of autism spectrum disorders (ASDs) and other intellectual and developmental disabilities (IDD) has led to emerging evidence implicating a role for oxidative stress. However, understanding the strength of this association is made challenging by the use of a variety of purported biomarkers of oxidative stress, many of which have either uncertain specificity or flawed methods of analysis. This review aims to address this issue, which is widespread in the ASD and IDD literature, by providing readers with information concerning the strengths and limitations of the choice and analysis of biomarkers of oxidative stress. We highlight that biomarkers and assays should be specific, sensitive, reproducible, precise, robust, and chosen with careful consideration. Future studies should be sufficiently powered and address sample collection, processing, and storage which are, additionally, poorly considered, sources of bad practice, and potential errors. Only with these issues considered, will the data lead to conclusions as to the precise role of oxidative stress in ASDs and IDD.
- Abstract: As Provided
- Publication Date: 2021
- Accession Number: EJ1294300
- Availability:
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