Autism Spectrum Disorder Symptoms Are Associated with Connectivity between Large-Scale Neural Networks and Brain Regions Involved in Social Processing

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  • Additional Information
    • Availability:
      Springer. Available from: Springer Nature. 233 Spring Street, New York, NY 10013. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-348-4505; e-mail: [email protected]; Web site: https://link.springer.com/
    • Peer Reviewed:
      Y
    • Source:
      14
    • Sponsoring Agency:
      National Institutes of Health (DHHS)
    • Contract Number:
      R01MH102224
      R01DK103691
      R21DK102052
      K01DK100445
      UL1TR002535
    • Subject Terms:
      Autism; Pervasive Developmental Disorders; Brain Hemisphere Functions; Cognitive Processes; Social Behavior; Diagnostic Tests; Scores
    • Subject Terms:
      Autism Diagnostic Observation Schedule
    • Accession Number:
      10.1007/s10803-020-04383-w
    • ISSN:
      0162-3257
    • Abstract:
      The neurobiology of autism spectrum disorder remains poorly understood. The present study addresses this knowledge gap by examining the relationship between functional brain connectivity and Autism Diagnostic Observation Schedule (ADOS) scores using publicly available data from the Autism Brain Imaging Data Exchange (ABIDE) database (N = 107). This relationship was tested across all brain voxels, without a priori assumptions, using a novel statistical approach. ADOS scores were primarily associated with decreased connectivity to right temporoparietal junction, right anterior insula, and left fusiform gyrus (p < 0.05, corrected). Seven large-scale brain networks influenced these associations. Findings largely encompassed brain regions involved in processing socially relevant information, highlighting the importance of these processes in autism spectrum disorder.
    • Abstract:
      As Provided
    • Publication Date:
      2020
    • Accession Number:
      EJ1262085