Auditory Event-Related Potentials and Associations with Sensory Patterns in Children with Autism Spectrum Disorder, Developmental Delay, and Typical Development

SAGE Publications. 2455 Teller Road, Thousand Oaks, CA 91320. Tel: 800-818-7243; Tel: 805-499-9774; Fax: 800-583-2665; e-mail: [email protected]; Web site: http://sagepub.com

Y

18

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (NIH)

R01HD042168
T32HD040127

Autism; Pervasive Developmental Disorders; Brain Hemisphere Functions; Diagnostic Tests; Auditory Perception; Auditory Stimuli; Sensory Integration; Developmental Delays; Comparative Analysis; Responses; Attention Control; Child Behavior; Observation; Rating Scales; Severity (of Disability); Children; Motor Development; Cognitive Ability; Young Children; Symptoms (Individual Disorders); Tactual Perception; Correlation; Intonation

Autism Diagnostic Observation Schedule; Childhood Autism Rating Scale; Mullen Scales of Early Learning

10.1177/1362361319893196

1362-3613

Atypical sensory response patterns are common in children with autism and developmental delay. Expanding on previous work, this observational electroencephalogram study assessed auditory event-related potentials and their associations with clinically evaluated sensory response patterns in children with autism spectrum disorder (n = 28), developmental delay (n = 17), and typical development (n = 39). Attention-orienting P3a responses were attenuated in autism spectrum disorder relative to both developmental delay and typical development, but early sensory N2 responses were attenuated in both autism spectrum disorder and developmental delay relative to typical development. Attenuated event-related potentials involving N2 or P3a components, or a P1 × N2 interaction, were related to more severe hyporesponsive or sensory-seeking response patterns across children with autism spectrum disorder and developmental delay. Thus, although attentional disruptions may be unique to autism spectrum disorder, sensory disruptions appear across developmental delay and are associated with atypical sensory behaviors.

As Provided

2020

EJ1257797