Autism with and without Regression: A Two-Year Prospective Longitudinal Study in Two Population-Derived Swedish Cohorts

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  • Additional Information
    • Availability:
      Springer. Available from: Springer Nature. 233 Spring Street, New York, NY 10013. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-348-4505; e-mail: [email protected]; Web site: https://link.springer.com/
    • Peer Reviewed:
      Y
    • Source:
      10
    • Subject Terms:
      Autism; Pervasive Developmental Disorders; Genetics; Symptoms (Individual Disorders); Severity (of Disability); Intellectual Disability; Language Impairments; Etiology; Young Children; Longitudinal Studies; Cohort Analysis; Foreign Countries
    • Subject Terms:
      Sweden
    • Accession Number:
      10.1007/s10803-018-03871-4
    • ISSN:
      0162-3257
    • Abstract:
      Two community-based cohorts of children with autism spectrum disorder, examined using similar assessment protocols, were pooled (n = 301) and subdivided according to history of regression. Those with regression (n = 62), 20.5% of the combined cohort, were contrasted with those without regression (n = 241) at first assessment (age range 19-60 months) and at 2-year follow-up on a range of measures. The regression group was significantly more functionally impaired, with regard to intellectual function (p < .001), language development (p < 0.001), and to severity of autism (p < 0.01) at both T1 and T2. Only 14 (23.3%) had a clearly identified underlying etiology [24 (18.6%) in the non-regressive group]. There were no significant differences between those who had regressed 'from normal' and those who had regressed 'from low' functioning.
    • Abstract:
      As Provided
    • Publication Date:
      2019
    • Accession Number:
      EJ1217794