Gastrointestinal Dysfunctions as a Risk Factor for Sleep Disorders in Children with Idiopathic Autism Spectrum Disorder: A Retrospective Cohort Study

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  • Additional Information
    • Availability:
      SAGE Publications. 2455 Teller Road, Thousand Oaks, CA 91320. Tel: 800-818-7243; Tel: 805-499-9774; Fax: 800-583-2665; e-mail: [email protected]; Web site: http://sagepub.com
    • Peer Reviewed:
      Y
    • Source:
      11
    • Sponsoring Agency:
      National Institute of Mental Health (DHHS/NIH)
      National Institutes of Health (DHHS)
    • Contract Number:
      1U24MH081810
      R21MH105822
    • Subject Terms:
      Risk; Sleep; Autism; Pervasive Developmental Disorders; Symptoms (Individual Disorders); Medical Evaluation; Diseases; Quality of Life; Incidence; Severity (of Disability); Age Differences; Gender Differences; Comparative Analysis; Identification; Behavior Problems; Children; Adolescents; Young Children; Toddlers; Statistical Analysis
    • Accession Number:
      10.1177/1362361316667061
    • ISSN:
      1362-3613
    • Abstract:
      Sleep disorders often co-occur with autism spectrum disorder. They further exacerbate autism spectrum disorder symptoms and interfere with children's and parental quality of life. This study examines whether gastrointestinal dysfunctions increase the odds of having sleep disorders in 610 children with idiopathic autism spectrum disorder, aged 2-18 years, from the Autism Genetic Resource Exchange research program. The adjusted odds ratio for sleep disorder among those with gastrointestinal dysfunctions compared to those without was 1.74 (95% confidence interval: 1.22-2.48). In addition, the odds of having multiple sleep disorder symptoms among children with gastrointestinal dysfunctions, adjusted for age, gender, behavioral problems, bed wetting, current and past supplements, and current and past medications for autism spectrum disorder symptoms were 1.75 (95% confidence interval: 1.10-2.79) compared to children without gastrointestinal dysfunctions. Early detection and treatment of gastrointestinal dysfunctions in autism spectrum disorder may be means to reduce prevalence and severity of sleep problems and improve quality of life and developmental outcomes in this population.
    • Abstract:
      As Provided
    • Number of References:
      37
    • Publication Date:
      2017
    • Accession Number:
      EJ1155972