White Matter and Development in Children with an Autism Spectrum Disorder

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Availability:
      SAGE Publications. 2455 Teller Road, Thousand Oaks, CA 91320. Tel: 800-818-7243; Tel: 805-499-9774; Fax: 800-583-2665; e-mail: [email protected]; Web site: http://sagepub.com
    • Peer Reviewed:
      Y
    • Source:
      17
    • Subject Terms:
      Brain; Children; Autism; Pervasive Developmental Disorders; Age Differences; Child Development; Early Adolescents; Comparative Analysis; Correlation; Brain Hemisphere Functions; Neurological Impairments; Cognitive Development
    • Subject Terms:
      Canada (Toronto)
    • Subject Terms:
      Autism Diagnostic Observation Schedule
    • Accession Number:
      10.1177/1362361312442596
    • ISSN:
      1362-3613
    • Abstract:
      Recent research suggests that brain development follows an abnormal trajectory in children with autism spectrum disorders (ASD). The current study examined changes in diffusivity with age within defined white matter tracts in a group of typically developing children and a group of children with an ASD, aged 6 to 14 years. Age by group interactions were observed for frontal, long distant, interhemispheric and posterior tracts, for longitudinal, radial and mean diffusivity, but not for fractional anisotropy. In all cases, these measures of diffusivity decreased with age in the typically developing group, but showed little or no change in the ASD group. This supports the hypothesis of an abnormal developmental trajectory of white matter in this population, which could have profound effects on the development of neural connectivity and contribute to atypical cognitive development in children with ASD.
    • Abstract:
      As Provided
    • Number of References:
      56
    • Publication Date:
      2014
    • Accession Number:
      EJ1019177