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L-Carnitine Supplementation Improves the Behavioral Symptoms in Autistic Children
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- Author(s): Fahmy, Sarah Farid; El-hamamsy, Manal H.; Zaki, Osama K.
- Language:
English- Source:
Research in Autism Spectrum Disorders. Jan 2013 7(1):159-166.- Physical Description:
PDF- Publication Date:
2013- Document Type:
Journal Articles
Reports - Research - Language:
- Additional Information
- Availability: Elsevier. 3251 Riverport Lane, Maryland Heights, MO 63043. Tel: 800-325-4177; Tel: 314-447-8000; Fax: 314-447-8033; e-mail: [email protected]; Web site: http://www.elsevier.com
- Peer Reviewed: Y
- Source: 8
- Subject Terms:
- Accession Number: 10.1016/j.rasd.2012.07.006
- ISSN: 1750-9467
- Abstract: L-Carnitine was proposed as a potential treatment for patients diagnosed with autism to ameliorate the behavioral symptoms associated with the disease. Thirty children diagnosed with autism were randomly assigned to receive (100 mg/kg bodyweight/day) of liquid L-carnitine (n = 16) or placebo (n = 14) for 6 months. Measurements included changes in childhood autism rating scale (CARS) form and free and total carnitine levels using tandem mass spectrometry. Results showed significant improvement in CARS scores (P-groups less than 0.001) and (P-overtime = 0.006), with statistically significant differences in free carnitine levels (P = 0.027) and total carnitine levels (P = 0.036). There was no correlation between baseline free and total carnitine levels with changes in CARS scores from zero to 6 months (r greater than 0.5, P greater than 0.05) and generally L-carnitine therapy was well tolerated. In conclusion, L-carnitine therapy (100 mg/kg bodyweight/day) administered for 6 months significantly improved the autism severity, but subsequent studies are recommended. (Contains 9 tables.)
- Abstract: As Provided
- Publication Date: 2013
- Accession Number: EJ1006134
- Availability:
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