Characteristics and prognosis of KI-1 positive anaplastic large cell lymphoma in Asians.

Publisher: Adis Press Country of Publication: Australia NLM ID: 1264322 Publication Model: Print Cited Medium: Print ISSN: 0004-8291 (Print) Linking ISSN: 00048291 NLM ISO Abbreviation: Aust N Z J Med Subsets: MEDLINE

Publication: Balgowlah, NSW : Adis Press
Original Publication: Sydney, Royal Australasian College of Physicians,

Lymphoma, Large-Cell, Anaplastic*/diagnosis ; Lymphoma, Large-Cell, Anaplastic*/epidemiology ; Lymphoma, Large-Cell, Anaplastic*/therapy; Ethnicity/*statistics & numerical data; Adolescent ; Adult ; Aged ; Antibiotics, Antineoplastic/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; China/ethnology ; Disease-Free Survival ; Female ; Humans ; Incidence ; India/ethnology ; Male ; Middle Aged ; Prognosis ; Retrospective Studies

Background: Ki-1 positive anaplastic large cell lymphoma is a rare type of non-Hodgkin's lymphoma (NHL), and has not been extensively described in Asian patients.
Aim: To evaluate the clinical characteristics, prognostic factors and treatment outcome of Ki-1 positive lymphoma in an Asian community.
Methods: A retrospective analysis of all patients with CD30 antigen positive anaplastic large cell lymphoma from 1987 to 1996 in a single institution.
Results: Of 218 patients with NHL, ten (5%) were identified with Ki-1 positive anaplastic large cell lymphoma. Eight were Chinese, two Indians. The male:female ratio was 1.5:1, and the median age was 32 years. Seven patients presented with B-symptoms, and five had stage III/IV disease. The majority (seven of ten) was low- or low-intermediate risk according to the International Prognostic Index (IPI). Four out of five cases immunophenotyped showed a T-cell origin. Five out of eight patients who received first-line combination chemotherapy achieved a complete remission. Two relapsed, with one being re-induced into a durable second remission. One patient with recurrent cutaneous lymphoma received solely radiotherapy and was disease-free at 20+ years from diagnosis. At analysis, two patients had died, five were disease-free at four, 27, 78, 89 months and 20 years respectively, and three were alive with disease. The IPI appears to have prognostic significance.
Conclusion: Incidence and clinical characteristics in our Asian patients were similar to those described in Western populations. The IPI appears to have prognostic relevance. In approximately one-third of patients, long term survival can be achieved with standard treatment.

0 (Antibiotics, Antineoplastic)

Date Created: 19990211 Date Completed: 19990414 Latest Revision: 20211203

20231215

10.1111/j.1445-5994.1998.tb01555.x

9972408