[Development of an immuno-neutral lipid emulsion for optimal postoperative management of intensive care patients].

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  • Author(s): Grimm H;Grimm H; Schott J; Schwemmle K
  • Source:
    Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress [Langenbecks Arch Chir Suppl Kongressbd] 1998; Vol. 115, pp. 599-604.
  • Publication Type:
    English Abstract; Journal Article
  • Language:
    German
  • Additional Information
    • Transliterated Title:
      Entwicklung einer immunneutralen Lipidemulsion zur optimalen postoperativen Therapie intensivmedizinischer Patienten.
    • Source:
      Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 9200456 Publication Model: Print Cited Medium: Print ISSN: 0942-2854 (Print) Linking ISSN: 09422854 NLM ISO Abbreviation: Langenbecks Arch Chir Suppl Kongressbd Subsets: MEDLINE
    • Publication Information:
      Original Publication: Berlin ; New York : Springer-Verlag, c1991-c1998.
    • Subject Terms:
      Critical Care* ; Fat Emulsions, Intravenous* ; Parenteral Nutrition, Total* ; Postoperative Care*; Animals ; Cytokines/physiology ; Fatty Acids, Omega-3/administration & dosage ; Fatty Acids, Omega-6 ; Fatty Acids, Unsaturated/administration & dosage ; Graft Rejection/immunology ; Graft Rejection/prevention & control ; Humans ; Immune Tolerance/immunology ; Kidney Transplantation/immunology ; Male ; Rats ; Rats, Inbred WKY
    • Abstract:
      Lipid emulsions prolong the rejection of allogeneic rat heart grafts in relation to their n-3 to n-6 fatty acid ratio. Because of the predominance of n-6 fatty acids soybean oil, which is clinically applied, shows an immunosuppressive effect. An n-3 to n-6 fatty acid ratio of 1 to 2 proved to be immunoneutral. Intravenous fat emulsions with an impaired n-3 to n-6 fatty acid ratio reduce cytokine release, infiltration and proliferation of immunocompetent cells. Lipids rich in n-3 fatty acids additionally reduce the release of the potent vasoconstrictor thromboxane A3 and increase the synthesis of leukotriene B5, which unlike leukotriene B4 does not activate polymorphonuclear neutrophils. Based on our results, the production of a clinically applicable lipid emulsion with a n-3 to n-6 fatty acid ratio of 1 to 2 can be recommended for the optimal parenteral nutrition of ICU patients with a markedly reduced immune system.
    • Accession Number:
      0 (Cytokines)
      0 (Fat Emulsions, Intravenous)
      0 (Fatty Acids, Omega-3)
      0 (Fatty Acids, Omega-6)
      0 (Fatty Acids, Unsaturated)
    • Publication Date:
      Date Created: 19990205 Date Completed: 19990407 Latest Revision: 20151119
    • Publication Date:
      20231215
    • Accession Number:
      9931686