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Airway oxidative stress and inflammation markers in exhaled breath from children are linked with exposure to black carbon.
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- Author(s): De Prins, Sofie1,2 ; Dons, Evi1 ; Van Poppel, Martine1 ; Int Panis, Luc1,3 ; Van de Mieroop, Els4 ; Nelen, Vera4 ; Cox, Bianca5 ; Nawrot, Tim S.5 ; Teughels, Caroline6 ; Schoeters, Greet1,2 ; Koppen, Gudrun1
- Source:
Environment International. Dec2014, Vol. 73, p440-446. 7p.- Subject Terms:
- Source:
- Additional Information
- Abstract: Background The current study aimed at assessing the associations between black carbon (BC) exposure and markers for airway inflammation and oxidative stress in primary school children in a Western European urban area. Methods In 130 children aged 6–12 years old, the fraction of exhaled nitric oxide (FeNO), exhaled breath condensate (EBC) pH, 8-isoprostane and interleukin (IL)-1β were measured in two seasons. BC concentrations on the sampling day (2-h average, 8:00–10:00 AM) and on the day before (24-h average) were assessed using measurements at a central monitoring site. Land use regression (LUR) models were applied to estimate weekly average BC exposure integrated for the time spent at home and at school, and seasonal average BC exposure at the home address. Associations between exposure and biomarkers were tested using linear mixed effect regression models. Next to single exposure models, models combining different BC exposure metrics were used. Results In single exposure models, an interquartile range (IQR) increase in 2-h BC (3.10 μg/m 3 ) was linked with a 5.9% (95% CI: 0.1 to 12.0%) increase in 8-isoprostane. FeNO increased by 16.7% (95% CI: 2.2 to 33.2%) per IQR increase in 24-h average BC (4.50 μg/m 3 ) and by 12.1% (95% CI: 2.5 to 22.8%) per IQR increase in weekly BC (1.73 μg/m 3 ). IL-1β was associated with weekly and seasonal (IQR = 1.70 μg/m 3 ) BC with respective changes of 38.4% (95% CI: 9.0 to 75.4%) and 61.8% (95% CI: 3.5 to 153.9%) per IQR increase in BC. An IQR increase in weekly BC was linked with a lowering in EBC pH of 0.05 (95% CI: − 0.10 to − 0.01). All associations were observed independent of sex, age, allergy status, parental education level and meteorological conditions on the sampling day. Most of the associations remained when different BC exposure metrics were combined in multiple exposure models, after additional correction for sampling period or after exclusion of children with airway allergies. In additional analyses, FeNO was linked with 24-h PM 10 levels, but the effect size was smaller than for BC. 8-Isoprostane was not linked with either 2-h or 24-h concentrations of PM 2.5 or PM 10 . Conclusion BC exposure on the morning of sampling was associated with airway oxidative stress while 24-h and weekly exposures were linked with airway inflammation. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Environment International is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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