[Clinical picture and pathology of the so-called vinyl chloride disease].

Klinik und Pathologie der sog. Vinylchlorid-Krankheit

Publisher: Urban Und Vogel Country of Publication: Germany NLM ID: 2984763R Publication Model: Print Cited Medium: Print ISSN: 0015-8178 (Print) Linking ISSN: 00158178 NLM ISO Abbreviation: Fortschr Med Subsets: MEDLINE

Publication: Munchen : Urban Und Vogel
Original Publication: Munich, [etc.], Verlag Fortschritte der Medizin.

Occupational Diseases/*chemically induced ; Vinyl Chloride/*poisoning ; Vinyl Compounds/*poisoning; Animals ; Chemical and Drug Induced Liver Injury/diagnosis ; Chemical and Drug Induced Liver Injury/etiology ; Environmental Exposure ; Fingers/drug effects ; Hemangiosarcoma/chemically induced ; Humans ; Liver/drug effects ; Liver Neoplasms/chemically induced ; Methods ; Osteolysis/chemically induced ; Osteolysis/diagnostic imaging ; Rabbits ; Radiography ; Raynaud Disease/chemically induced ; Scleroderma, Systemic/chemically induced ; Vinyl Chloride/toxicity

About 26 years ago symptoms of liver and spleen were described for the first time by Tribukh et al. in laborers exposed to vinyl chloride. Besides these symptoms sclerodermia, acroosteolysis and Raynaud's phaenomenon are known to be typical for the VC disease. Rather high concentrations of VC seem to be necessary to cause this disease. After cessation of exposure the symptoms may improve partly. Haemangiosarcoma of the liver may occur as the most serious effect of prolonged exposure to vinyl chloride. Presently 48 cases induced by VC exposure are observed all over the world. Diagnosis is difficult, the prognosis of this cancer is practically always fatal. The improvement of working places by the chemical industries should further reduce the risk of acquiring VC disease as well as haemangioma of the liver due to VC exposure.

0 (Vinyl Compounds)
WD06X94M2D (Vinyl Chloride)

Date Created: 19760916 Date Completed: 19761223 Latest Revision: 20161123

20221208

987982