The long-term outcome of cystinuria in Japan.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Karger Country of Publication: Switzerland NLM ID: 0417373 Publication Model: Print Cited Medium: Print ISSN: 0042-1138 (Print) Linking ISSN: 00421138 NLM ISO Abbreviation: Urol Int Subsets: MEDLINE
    • Publication Information:
      Publication: Basel : Karger
      Original Publication: Basel.
    • Subject Terms:
      Chelating Agents/*therapeutic use ; Cystinuria/*drug therapy ; Penicillamine/*therapeutic use ; Tiopronin/*therapeutic use; Adult ; Cystine/metabolism ; Cystinuria/complications ; Cystinuria/urine ; Female ; Follow-Up Studies ; Humans ; Hydrogen-Ion Concentration ; Japan ; Male ; Recurrence ; Treatment Outcome ; Urinary Calculi/diagnosis ; Urinary Calculi/drug therapy ; Urinary Calculi/etiology
    • Abstract:
      Recurrence of growth of urinary stone is frequently observed during the clinical course of cystinuria patients. The aim of the present study is to examine the long-term outcome of cystinuria in Japan and clarify the effects of medical treatment on urinary stone. Thirty-one patients with cystinuria who had been followed up longer than 6 months were included. The follow-up period was 6-264 months with a mean of 89.5 months. Stone event was defined as appearance of new stone or radiological evidence of stone growth. All patients were managed with forced hydration and urine alkalization. Twenty-eight patients were treated with administration of thiol such as D-penicillamine or alpha-mercaptopropionylglycine. Stone events per year ranged from 0 to 1.09 with a median of 0.09. Stone events per patient-year was 0.19 for all patients. The average urinary cystine concentration during treatment in the favorable outcome group (stone events per year < 0.3) was lower that that in the unfavorable outcome group (stone events per year >/=0.3); 221.2 +/- 75.2 vs. 303.3 +/- 93.5 mg/l, although the difference was not statistically significant. Prognosis of urinary stone in Japanese patients with cystinuria was relatively good with large variation. The medical treatment to reduce urinary cystine concentration would be useful for the management of cystinuria.
    • Accession Number:
      0 (Chelating Agents)
      48TCX9A1VT (Cystine)
      C5W04GO61S (Tiopronin)
      GNN1DV99GX (Penicillamine)
    • Publication Date:
      Date Created: 19990105 Date Completed: 19990219 Latest Revision: 20180213
    • Publication Date:
      20221213
    • Accession Number:
      10.1159/000030294
    • Accession Number:
      9873246