Chemistry: Chemical con artists foil drug discovery.

The author discusses aspects of drug discoveries by scientists without appropriate guidance and attempts to optimize the activity of reactive Pan-assay interference compounds (PAINS) like curcumin. He criticizes false revalidation of these molecules as good drug leads by medical publications. Topics include protein inhibitors, effects on biomedical-research work, Library of Pharmacologically Active Compounds (LOPAC) by chemical supplier Sigma Aldrich and protein binding.