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Dopamine D1 and D2 receptor selectivities of phenyl-benzazepines in rhesus monkey striata.
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- Author(s): Weed MR;Weed MR; Woolverton WL; Paul IA
- Source:
European journal of pharmacology [Eur J Pharmacol] 1998 Nov 13; Vol. 361 (1), pp. 129-42.
- Publication Type:
Journal Article; Research Support, U.S. Gov't, P.H.S.
- Language:
English
- Additional Information
- Source:
Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print Cited Medium: Print ISSN: 0014-2999 (Print) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE
- Publication Information:
Publication: 2005- : Amsterdam : Elsevier Science
Original Publication: Amsterdam, North Holland Pub. Co.
- Subject Terms:
- Abstract:
Several phenyl-benzazepine compounds, putatively selective dopamine D1 receptor agonists, have been used to study the effects of dopamine D1 receptor stimulation in rodents and nonhuman primates. However, the dopamine receptor selectivities of these compounds have not been established in nonhuman primates. Accordingly, the relative selectivities of six phenyl-benzazepines for dopamine D1-like and D2-like receptors were assessed in rhesus monkey and, for comparison, rat striata. The compounds tested had higher affinity for D1 than D2 receptors in both species; however, their selectivity varied by up to three orders of magnitude. GTP (100 microM) reduced agonist binding at the high-affinity state of the dopamine D1 receptor, but the magnitude of the effect of GTP did not reliably predict a compound's efficacy. Furthermore, a history of cocaine self-administration did not appear to influence dopamine receptor binding characteristics in the rhesus monkeys in this study. The present results will aid the comparison of dopamine receptor binding characteristics and behavioral effects of D1 dopamine receptor agonists.
- Grant Information:
DA-05616 United States DA NIDA NIH HHS; DA-10352 United States DA NIDA NIH HHS; RR 00163 United States RR NCRR NIH HHS
- Accession Number:
0 (Benzazepines)
0 (Dopamine Agonists)
0 (Dopamine Antagonists)
0 (Receptors, Dopamine D1)
0 (Receptors, Dopamine D2)
10028-17-8 (Tritium)
4X6E73CJ0Q (Spiperone)
80751-65-1 (SK&F 82958)
86-01-1 (Guanosine Triphosphate)
- Publication Date:
Date Created: 19981216 Date Completed: 19990304 Latest Revision: 20190624
- Publication Date:
20231215
- Accession Number:
10.1016/s0014-2999(98)00669-4
- Accession Number:
9851550
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