A low interleukin-10 tumor necrosis factor-alpha ratio is associated with malaria anemia in children residing in a holoendemic malaria region in western Kenya.

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  • Additional Information
    • Source:
      Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Print ISSN: 0022-1899 (Print) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE
    • Publication Information:
      Publication: Jan. 2011- : Oxford : Oxford University Press
      Original Publication: 1904-2010 : Chicago, IL : University of Chicago Press
    • Subject Terms:
      Anemia/*blood ; Anemia/*immunology ; Interleukin-10/*blood ; Malaria, Falciparum/*blood ; Malaria, Falciparum/*immunology ; Tumor Necrosis Factor-alpha/*metabolism; Anemia/etiology ; Case-Control Studies ; Child ; Child, Preschool ; Cross-Sectional Studies ; Down-Regulation ; Humans ; Kenya ; Malaria, Falciparum/complications ; Models, Biological
    • Abstract:
      The balance between Th1 cytokines (tumor necrosis factor [TNF]-alpha, interferon [IFN]-gamma) and Th2 cytokines (interleukin [IL]-10, -4) may be critical in the development of severe falciparum malaria. Therefore, plasma concentrations of these cytokines were determined in children with various manifestations of malaria. Plasma levels of IFN-gamma and IL-4 were undetectable in most children. However, TNF-alpha and IL-10 were significantly elevated in children with high-density parasitemia and malaria anemia compared with children in control groups. In children with mild malaria, IL-10, but not TNF-alpha, was significantly elevated. While the highest concentrations of TNF-alpha were found in children with malaria anemia, IL-10 levels were highest in children with high-density uncomplicated malaria. The mean ratio of IL-10 to TNF-alpha was significantly higher in children with mild and high-density parasitemia (4.64, P<.005) than in children with malaria anemia (1.77). Thus, higher levels of IL-10 over TNF-alpha may prevent development of malaria anemia by controlling the excessive inflammatory activities of TNF-alpha.
    • Comments:
      Comment in: J Infect Dis. 1999 Nov;180(5):1753-5. (PMID: 10515852)
    • Accession Number:
      0 (Tumor Necrosis Factor-alpha)
      130068-27-8 (Interleukin-10)
    • Publication Date:
      Date Created: 19981208 Date Completed: 19990203 Latest Revision: 20061115
    • Publication Date:
      20231215
    • Accession Number:
      10.1086/314548
    • Accession Number:
      9841855