[Autoantibodies against coagulation factor VIII].

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  • Additional Information
    • Transliterated Title:
      Autoantistoffer mod koagulationsfaktor VIII.
    • Source:
      Publisher: Den Alm Danske Laegerforening Country of Publication: Denmark NLM ID: 0141730 Publication Model: Print Cited Medium: Print ISSN: 0041-5782 (Print) Linking ISSN: 00415782 NLM ISO Abbreviation: Ugeskr Laeger Subsets: MEDLINE
    • Publication Information:
      Original Publication: Copenhagen : Den Alm Danske Laegerforening
    • Subject Terms:
      Autoantibodies*/analysis ; Autoantibodies*/biosynthesis; Blood Coagulation Disorders/*immunology ; Factor VIII/*immunology; Blood Coagulation Disorders/diagnosis ; Blood Coagulation Disorders/drug therapy ; Hemorrhage/diagnosis ; Hemorrhage/drug therapy ; Hemorrhage/immunology ; Humans
    • Abstract:
      Autoantibodies towards coagulation factor VIII is a rare disease, incidence 1 pr. 2.5-5 million/year. The symptoms are most often subcutaneous or intramuscular haemorrhages or uncontrollable bleeding after minimal traumas. Screening tests show prolonged activated partial thromboplastin time, normal prothrombin time and thrombocyte count. Production of autoantibodies is controlled by prednisolone which may be supplemented with chemotherapy, i.e. azathioprine. Bleeding can be controlled by using coagulation factor concentrates that bypass factor VIII. If diagnosed early, there is a good chance of both stopping bleeding and suppressing autoantibody production. In order to be able to detect patients at risk of having factor VIII autoantibodies, it is recommended to screen all bleeding patients using activated partial thromboplastin time, prothrombin time and thrombocyte count. All patients showing isolated prolonged activated partial thrombin time should be referred to a laboratory specialized in coagulation problems for immediate evaluation.
    • Number of References:
      40
    • Accession Number:
      0 (Autoantibodies)
      9001-27-8 (Factor VIII)
    • Publication Date:
      Date Created: 19981104 Date Completed: 19981109 Latest Revision: 20061115
    • Publication Date:
      20240829
    • Accession Number:
      9800508