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Pharmacokinetics of oral fluconazole in premature infants.
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- Additional Information
- Source:
Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7603873 Publication Model: Print Cited Medium: Print ISSN: 0340-6199 (Print) Linking ISSN: 03406199 NLM ISO Abbreviation: Eur J Pediatr Subsets: MEDLINE
- Publication Information:
Publication: Berlin : Springer Verlag
Original Publication: Berlin, New York, Springer-Verlag.
- Subject Terms:
- Abstract:
Unlabelled: Systemic infections with Candida albicans in neonates are a frequent and well recognized problem. The therapeutic gold standard in this situation is the combined intravenous antimycotic treatment with amphotericin B and flucytosine. Potential adverse effects of this regimen have encouraged the search for desirable alternatives. We report on the use of oral fluconazole in neonates with Candida albicans septicaemia. Three premature infants were treated with four courses of therapy. Pharmacokinetic studies were performed during each course. At oral doses of 4.5-6 mg/kg once a day, serum levels of fluconazole were within the therapeutic range during the entire dosage interval. Follow up showed microbiological and clinical cure in all patients with no side-effects. In one patient a dosage of 4 mg/kg per day lead to a microbiological relapse with sub-therapeutic serum levels.
Conclusions: Oral fluconazole seems to be a safe and effective treatment for Candida albicans septicaemia even in premature infants.
- Accession Number:
0 (Antifungal Agents)
8VZV102JFY (Fluconazole)
- Publication Date:
Date Created: 19980904 Date Completed: 19981214 Latest Revision: 20220316
- Publication Date:
20231215
- Accession Number:
10.1007/s004310050906
- Accession Number:
9727851
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