Antiproliferative action of interferon-alpha requires components of T-cell-receptor signalling.

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    • Subject Terms:
      CELLULAR signal transduction; INTERFERONS; T cells; PHYSIOLOGY
    • Abstract:
      Presents research which showed that, unexpectedly, transmission of growth-inhibitory signals by interferon-alpha in T cells requires the expression and association of CD45, Lck and ZAP-70 with the interferon-alpha-receptor signaling complex. Signal transduction and initiation of cellular responses; Signaling components coupled to receptors, with examples.