Red cell age-related changes of hemoglobins AIa+b and AIc in normal and diabetic subjects.

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  • Author(s): Fitzgibbons JF; Koler RD; Jones RT
  • Source:
    The Journal of clinical investigation [J Clin Invest] 1976 Oct; Vol. 58 (4), pp. 820-4.
  • Publication Type:
    Journal Article; Research Support, U.S. Gov't, P.H.S.
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print Cited Medium: Print ISSN: 0021-9738 (Print) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
    • Publication Information:
      Publication: 1999- : Ann Arbor, MI : American Society for Clinical Investigation
      Original Publication: New Haven [etc.] American Society for Clinical Investigation.
    • Subject Terms:
      Erythrocyte Aging*; Diabetes Mellitus/*blood ; Erythrocytes/*analysis; Adult ; Aged ; Blood Glucose ; Female ; Humans ; Male ; Middle Aged
    • Abstract:
      The minor hemoglobin components, hemoglobin AIa+b and hemoglobin AIc, were measured in the 10% youngest and 10% oldest erythrocytes of 15 normal and 14 diabetic subjects. Erythrocyte fractions were obtained by centrifugation in isopyknic concentrations of dextran: 28.5% of 40,000-mol wt dextran yeilded the 10% lightest of young cells, and 30.5% dextran provided the 10% heaviest or old erythrocytes. Both normal and diabetic erythrocytes contain increased amounts of Hb AIa+b and Hb AIc in old as compared to young cells. In normal subjects, young cells contained 1.2+/-0.2%, and old cells contained 1.8+/-0.4% Hb AIa+b. Corresponding values for diabetic cells were 1.7+/-0.6 and 2.6+/-0.9%. Hb AIc increased from 3.1+/-0.8 to 6.0+/-1.1% in normals and from 5.1+/-2.1 to 10.1+/-3.7% in diabetics. The results indicate that both cell age and diabetes are significant determinants of the amounts of Hb AIa+b and Hb AIc.
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    • Accession Number:
      0 (Blood Glucose)
    • Publication Date:
      Date Created: 19761001 Date Completed: 19761201 Latest Revision: 20181113
    • Publication Date:
      20250114
    • Accession Number:
      PMC333244
    • Accession Number:
      10.1172/JCI108534
    • Accession Number:
      965489