The human autoantigen La/SS-B accelerates herpes simplex virus type 1 replication in transfected mouse 3T3 cells.

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  • Additional Information
    • Source:
      Publisher: Oxford University Press Country of Publication: England NLM ID: 0057202 Publication Model: Print Cited Medium: Print ISSN: 0009-9104 (Print) Linking ISSN: 00099104 NLM ISO Abbreviation: Clin Exp Immunol Subsets: MEDLINE
    • Publication Information:
      Publication: 2022- : Oxford : Oxford University Press
      Original Publication: Oxford : Blackwell Scientific Publications
    • Subject Terms:
      Autoantigens/*immunology ; Herpesvirus 1, Human/*physiology ; Ribonucleoproteins/*immunology ; Virus Replication/*immunology; 3T3 Cells ; Animals ; Gene Expression Regulation/immunology ; Humans ; Mice ; Transfection ; SS-B Antigen
    • Abstract:
      Permanently transfected mouse cell lines which expressed different levels of the human autoantigen La/SS-B were infected with different strains of herpes simplex virus type 1, including the strains ANG, HSZP, 17syn+ and HFEM. During infection the localization of the human La protein was followed using an anti-La MoAb, which recognized only the human La protein but did not cross-react with either the endogenous mouse La protein or any viral encoded protein. After infection La protein was transported from the nucleus to the cytoplasm. The time course of translocation was dependent on the amount of human La protein expressed in the respective cell line. Moreover, acceleration of viral replication was dependent on the level of expression of human La protein, suggesting that La protein is a cellular factor that facilitates virus replication.
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    • Accession Number:
      0 (Autoantigens)
      0 (Ribonucleoproteins)
    • Publication Date:
      Date Created: 19980702 Date Completed: 19980715 Latest Revision: 20231213
    • Publication Date:
      20231215
    • Accession Number:
      PMC1905003
    • Accession Number:
      10.1046/j.1365-2249.1998.00605.x
    • Accession Number:
      9649219