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Virus-induced cell death in plants expressing the mammalian 2',5' oligoadenylate system.
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- Author(s): Ogawa T;Ogawa T; Hori T; Ishida I
- Source:
Nature biotechnology [Nat Biotechnol] 1996 Nov; Vol. 14 (11), pp. 1566-9.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print Cited Medium: Print ISSN: 1087-0156 (Print) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE
- Publication Information: Publication: New York Ny : Nature America Publishing
Original Publication: New York, NY : Nature Pub. Co., [1996- - Subject Terms: Adenine Nucleotides/*biosynthesis ; Endoribonucleases/*genetics ; Oligoribonucleotides/*biosynthesis ; Plant Viruses/*genetics; Adenine Nucleotides/genetics ; Animals ; Cell Death/genetics ; Cucumovirus ; Endoribonucleases/biosynthesis ; Oligoribonucleotides/genetics ; Plants, Genetically Modified ; Plants, Toxic ; Potyvirus ; Nicotiana/virology ; Virus Replication/genetics
- Abstract: The major components of the 2-5A system, responsible for the mammalian interferon-induced antiviral response, are the 2',5' oligoadenylate synthetase (2-5Aase) and 2',5' oligoadenylate (2-5A) dependent ribonuclease (RNase L). Transgenic tobacco plants expressing these two enzyme activities were produced by crossing the transgenic plants expressing RNase L with those expressing 2-5Aase. The double transgenic plants showed complete resistance against cucumber mosaic virus (CMV), infection with necrotic spots only forming on the virus-inoculated leaf. On the other hand, although plants inoculated with potato virus Y (PVY) formed necrotic spots on the inoculated leaf and virus amplification could not be detected, all plants died within 20 days of inoculation. The transgenic tobacco plants expressing either 2-5Aase or RNase L activity showed typical disease symptoms with CMV- or PVY-inoculation. These results suggest that the introduced 2-5A system is activated in tobacco cells by dsRNA, the replicating intermediates of RNA viruses, leading to death of the host cells, which has not been observed in mammalian cells.
- Comments: Comment in: Nat Biotechnol. 1996 Nov;14(11):1538-9. (PMID: 9634815)
- Accession Number: 0 (Adenine Nucleotides)
0 (Oligoribonucleotides)
61172-40-5 (2',5'-oligoadenylate)
EC 3.1.- (Endoribonucleases)
EC 3.1.26.- (2-5A-dependent ribonuclease) - Publication Date: Date Created: 19961101 Date Completed: 19980814 Latest Revision: 20231213
- Publication Date: 20231215
- Accession Number: 10.1038/nbt1196-1566
- Accession Number: 9634822
- Source:
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