Association between maternal inflammatory bowel disease and adverse perinatal outcomes.

PREGNANCY complication risk factors; CONFIDENCE intervals; PREMATURE infants; INFLAMMATORY bowel diseases; LONGITUDINAL method; PLACENTA diseases; PREGNANCY complications; RESEARCH funding; ULCERATIVE colitis; RETROSPECTIVE studies; DATA analysis software; DESCRIPTIVE statistics; ODDS ratio; DISEASE complications

Objective:To examine whether inflammatory bowel disease (IBD) is associated with ischemic/inflammatory conditions during pregnancy.Study Design:A retrospective cohort study using the 2000 to 2012 Kaiser Permanente Southern California maternally-linked medical records (n=395 781). The two major subtypes of IBD, ulcerative colitis and Crohn's diseases were studied. Adjusted odds ratios (ORs) were used to quantify the associations.Result:A pregnancy complicated by IBD was associated with increased incidence of small-for-gestational age birth (OR=1.46, 95% confidence interval (CI)=1.14 to 1.88), spontaneous preterm birth (OR=1.32, 95% CI=1.00 to 1.76) and preterm premature rupture of membranes (OR=1.95, 95% CI=1.26 to 3.02). Further stratifying by IBD subtypes, only ulcerative colitis was significantly associated with increased incidence of ischemic placental disease, spontaneous preterm birth and preterm premature rupture of membranes.Conclusion:The findings underscore the potential impact of maternal IBD on adverse perinatal outcomes. Clinicians should be aware that the association between IBD and adverse perinatal outcome varies by IBD subtypes. [ABSTRACT FROM AUTHOR]

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