Enhanced protein C activation and inhibition of fibrinogen cleavage by a thrombin modulator.

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    • Abstract:
      Discusses LY254603, a modulator of the enzymatic activity of human thrombin. LY254603's enhancement of the thrombin-catalyzed generation of the anticoagulant factor activated protein C; LY254603's inhibition of thrombin-dependent fibrinogen clotting; The effects of LY254603 on the stimulation of protein C cleavage and reduction of fibrinogen cleaving ability; The potential of the compound to represent a prototype of a class of agents with similar abilities.