Regression of subcutaneous lymphoma following removal of an ovarian granulosatheca cell tumor in a horse.

Publisher: American Veterinary Medical Association Country of Publication: United States NLM ID: 7503067 Publication Model: Print Cited Medium: Print ISSN: 0003-1488 (Print) Linking ISSN: 00031488 NLM ISO Abbreviation: J Am Vet Med Assoc Subsets: MEDLINE

Publication: Mar. 1975- : Schaumburg, Ill. : American Veterinary Medical Association
Original Publication: Ithaca, N.Y. : [American Veterinary Medical Association, 1915]-

Neoplasms, Multiple Primary*/pathology ; Neoplasms, Multiple Primary*/physiopathology ; Neoplasms, Multiple Primary*/surgery; Granulosa Cell Tumor/*veterinary ; Horse Diseases/*surgery ; Lymphoma, Non-Hodgkin/*veterinary ; Ovarian Neoplasms/*veterinary ; Thecoma/*veterinary; Animals ; Biopsy, Needle/veterinary ; Female ; Granulosa Cell Tumor/pathology ; Granulosa Cell Tumor/surgery ; Horse Diseases/pathology ; Horse Diseases/physiopathology ; Horses ; Lymphoma, Non-Hodgkin/pathology ; Lymphoma, Non-Hodgkin/physiopathology ; Neoplasm Recurrence, Local/etiology ; Neoplasm Recurrence, Local/veterinary ; Neoplasm Regression, Spontaneous ; Ovarian Neoplasms/pathology ; Ovarian Neoplasms/surgery ; Periodicity ; Progesterone Congeners/therapeutic use ; Receptors, Progesterone/analysis ; Thecoma/pathology ; Thecoma/surgery ; Trenbolone Acetate/analogs & derivatives ; Trenbolone Acetate/therapeutic use

A 9-year-old Arabian mare was admitted for evaluation of multiple subcutaneous nodules and infertility. Fine-needle aspiration of one of the subcutaneous nodules resulted in a cytologic diagnosis of histiolymphocytic lymphoma. Palpation per rectum and transrectal ultrasonography revealed a mass associated with the left ovary. Excision of the ovarian tumor was performed, and a histopathologic diagnosis of granulosa-theca cell tumor was made. After removal of the granulosa-theca cell tumor, subcutaneous nodules regressed. The referring veterinarian reported that the nodules had also disappeared and then recurred after administration of a synthetic progestin. To further characterize the lymphoma and investigate this possible hormonal relationship, immunophenotyping and estrogen and progesterone receptor assays were performed. The subcutaneous lymphoma was classified as a T-cell rich B-cell lymphoma, results of estrogen receptor assays were negative, and results of progesterone receptor assays were positive. Clinical observations of subcutaneous lymphoma in horses indicate that the waxing and waning nature of these tumors may be associated with the estrous cycle, pregnancy, foaling, and lactation. Clinical observations and identification of progesterone receptors suggest that a relationship between serum steroid hormone concentrations, such as estrogen and progesterone, and subcutaneous lymphoma may exists.

0 (Progesterone Congeners)
0 (Receptors, Progesterone)
2U0X0JA2NB (altrenogest)
RUD5Y4SV0S (Trenbolone Acetate)

Date Created: 19980520 Date Completed: 19980602 Latest Revision: 20151119

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