Sodium-dependent homo- and hetero-exchange of neutral amino acids mediated by the amino acid transporter ATB degree.

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  • Author(s): Torres-Zamorano V;Torres-Zamorano V; Leibach FH; Ganapathy V
  • Source:
    Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1998 Apr 28; Vol. 245 (3), pp. 824-9.
  • Publication Type:
    Journal Article; Research Support, U.S. Gov't, P.H.S.
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print Cited Medium: Print ISSN: 0006-291X (Print) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE
    • Publication Information:
      Publication: <2002- >: San Diego, CA : Elsevier
      Original Publication: New York, Academic Press.
    • Subject Terms:
    • Abstract:
      We have investigated the functional characteristics of the human amino acid transporter ATB degree using the Xenopus laevis oocyte expression system. When expressed in oocytes, ATB degree mediates the uptake of neutral amino acids in an Na(+)-dependent manner. In addition, this transporter is able to mediate the efflux of intracellular neutral amino acids in exchange with extracellular neutral amino acids. This homo- and hetero-exchange of amino acids is absolutely Na(+)-dependent and conforms strictly to the substrate specificity of ATB degree. Kinetic analysis indicates that the affinity of ATB degree for a given amino acid substrate is similar whether ATB degree catalyzes the influx of the amino acid or the amino acid-induced efflux of intracellular amino acids. These results demonstrate for the first time the ability of ATB degree to function as a homo- and hetero-exchanger for its substrates.
    • Grant Information:
      HD 24451 United States HD NICHD NIH HHS
    • Accession Number:
      0 (Amino Acid Transport Systems)
      0 (Amino Acid Transport Systems, Basic)
      0 (Amino Acid Transport Systems, Neutral)
      0 (Amino Acids)
      0 (Carrier Proteins)
      0 (SLC3A1 protein, human)
      9NEZ333N27 (Sodium)
    • Publication Date:
      Date Created: 19980520 Date Completed: 19980605 Latest Revision: 20190612
    • Publication Date:
      20240829
    • Accession Number:
      10.1006/bbrc.1998.8434
    • Accession Number:
      9588199