From fluoroquinolones to 2-pyridones.

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  • Author(s): Hooper, David C.
  • Source:
    Lancet. 5/13/1995, Vol. 345 Issue 8959, p1192. 2p. 1 Diagram.
  • Additional Information
    • Subject Terms:
      PYRIDONE; BIOCHEMICAL mechanism of action
    • Abstract:
      Opinion. Examines the antimicrobial mechanisms of 2-pyridones. Selective action of fluoroquinolones on prokaryote topoisomerases; 2-pyridones' ability to inhibit DNA gyrase and topoisomerase IV; Wide spectrum variants of 2-pyridone; Need to assess pyridones' tolerability and clinical efficacy in human beings.