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Out on a limb. (cover story)
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- Abstract:
he article discusses embryology in accordance with the PZ model. The model has tried to change the theory of limb development in embryos. The PZ model was proposed 30 years ago by biologist Lewis Wolpert of University College London to explain how a bunch of undistinguished cells transform themselves, in strict sequence, into the various parts of a wing, arm or leg. More fundamentally, the PZ model is often invoked to explain how other aspects of an embryo's development are orchestrated. It was proposed as a key mechanism in determining the main head-to-foot axis.The first idea about it came in August 2002, when scientists Clifford Tabin and Andrew Dudley of Harvard Medical School in Boston, Massachusetts along with Marian Ros from the University of Cantabria in Spain published some startling results in the journal 'Nature.'
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