Developmental regulation of erythropoietin and erythropoiesis.

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  • Author(s): Moritz KM;Moritz KM; Lim GB; Wintour EM
  • Source:
    The American journal of physiology [Am J Physiol] 1997 Dec; Vol. 273 (6), pp. R1829-44.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: American Physiological Society Country of Publication: United States NLM ID: 0370511 Publication Model: Print Cited Medium: Print ISSN: 0002-9513 (Print) Linking ISSN: 00029513 NLM ISO Abbreviation: Am J Physiol Subsets: MEDLINE
    • Publication Information:
      Publication: Bethesda, MD : American Physiological Society
      Original Publication: Washington [etc.] American Physiological Society.
    • Subject Terms:
      Embryonic and Fetal Development* ; Gene Expression Regulation, Developmental*; Aging/*physiology ; Erythropoiesis/*physiology ; Erythropoietin/*biosynthesis ; Receptors, Erythropoietin/*biosynthesis; Animals ; Humans ; Kidney/embryology ; Kidney/physiology ; Liver/embryology ; Liver/physiology ; RNA, Messenger/biosynthesis ; Receptors, Erythropoietin/genetics ; Transcription, Genetic
    • Abstract:
      It is well established that erythropoiesis occurs first in the yolk sac, then in the liver, subsequently moving to the bone marrow and, in rodents, the spleen during development. The origin of the erythropoietic precursors and some factors suggested to be important for the changing location of erythropoiesis are discussed in this review. Until recently, the major site of erythropoietin (Epo) production in the fetus was thought to be the liver, but studies have shown now that the Epo gene is expressed strongly in the fetal kidney, even in the temporary mesonephros. The metanephric Epo mRNA is upregulated by anemia, downregulated by glucocorticoids, and contributes substantially to circulating hormone levels in hemorrhaged ovine fetuses. Other sites of Epo and Epo receptor production, likely to have important actions during development, are the placenta and the brain.
    • Number of References:
      187
    • Accession Number:
      0 (RNA, Messenger)
      0 (Receptors, Erythropoietin)
      11096-26-7 (Erythropoietin)
    • Publication Date:
      Date Created: 19980122 Date Completed: 19980209 Latest Revision: 20190513
    • Publication Date:
      20250114
    • Accession Number:
      10.1152/ajpregu.1997.273.6.R1829
    • Accession Number:
      9435635