[Increased urea synthesis in patients with active inflammatory bowel disease].

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  • Additional Information
    • Transliterated Title:
      Accelereret urinstofsyntese hos patienter med aktiv inflammatorisk tarmsygdom.
    • Source:
      Publisher: Den Alm Danske Laegerforening Country of Publication: Denmark NLM ID: 0141730 Publication Model: Print Cited Medium: Print ISSN: 0041-5782 (Print) Linking ISSN: 00415782 NLM ISO Abbreviation: Ugeskr Laeger Subsets: MEDLINE
    • Publication Information:
      Original Publication: Copenhagen : Den Alm Danske Laegerforening
    • Subject Terms:
      Colitis, Ulcerative/*metabolism ; Crohn Disease/*metabolism ; Urea/*metabolism; Adult ; Amino Acids/administration & dosage ; Amino Acids/metabolism ; Blood Urea Nitrogen ; Colitis, Ulcerative/blood ; Colitis, Ulcerative/immunology ; Crohn Disease/blood ; Crohn Disease/immunology ; Female ; Humans ; Interleukins/analysis ; Liver/metabolism ; Male ; Nitrogen/metabolism ; Prospective Studies ; Tumor Necrosis Factor-alpha/analysis
    • Abstract:
      Patients with active inflammatory bowel disease are often reported to be in negative nitrogen balance. Therefore, we examined basal and amino acid stimulated urea synthesis in 11 patients with active inflammatory bowel disease and in 10 patients with non-active disease. A primed continuous infusion of an amino acid mixture was given from t = 1 h to t = 5 h; during the first and the last two hours no amino acid infusion was given. Urea nitrogen synthesis rate was quantified independently of changes in blood amino acid concentration by means of the functional hepatic nitrogen clearance, i.e. the linear slope of the regression of urea nitrogen synthesis rate on blood amino acid concentration. Basal and amino acid stimulated urea nitrogen synthesis rate as well as functional hepatic nitrogen clearance were elevated twofold in the patients with active disease. No differences between the two groups were observed as regards basal or stimulated plasma glucagon, cortisol, catecholamines and serum levels of interleukin-1 alpha, interleukin-1 beta, tumor necrosis factor-alpha and interleukin-6. The results show that liver function related to conversion of amino-nitrogen to urea is increased and may contribute to the less efficient nitrogen economy in patients with active inflammatory bowel disease.
    • Accession Number:
      0 (Amino Acids)
      0 (Interleukins)
      0 (Tumor Necrosis Factor-alpha)
      8W8T17847W (Urea)
      N762921K75 (Nitrogen)
    • Publication Date:
      Date Created: 19971231 Date Completed: 19971209 Latest Revision: 20131121
    • Publication Date:
      20231215
    • Accession Number:
      9411971