Penetration of tobramycin sulfate in the aqueous humor of the rabbit.

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  • Author(s): Uwaydah MM; Faris BM
  • Source:
    Archives of ophthalmology (Chicago, Ill. : 1960) [Arch Ophthalmol] 1976 Jul; Vol. 94 (7), pp. 1173-4.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: American Medical Association Country of Publication: United States NLM ID: 7706534 Publication Model: Print Cited Medium: Print ISSN: 0003-9950 (Print) Linking ISSN: 00039950 NLM ISO Abbreviation: Arch Ophthalmol Subsets: MEDLINE
    • Publication Information:
      Original Publication: Chicago, IL : American Medical Association
    • Subject Terms:
      Anti-Bacterial Agents/*metabolism ; Aqueous Humor/*metabolism ; Tobramycin/*metabolism; Animals ; Aqueous Humor/drug effects ; Conjunctiva ; Dose-Response Relationship, Drug ; Injections ; Rabbits ; Tobramycin/blood ; Tobramycin/pharmacology
    • Abstract:
      The intraocular penetration of tobramycin sulfate, a new aminoglycoside antibiotic, was evaluated in rabbits following subconjunctival injection. The mean tobramycin sulfate concentration in the aqueous humor 60 minutes after a single 5-mg dose was 5.5 mug/ml, as compared to a mean concentration of 6.7 mug/ml following a single 10-mg dose. These levels exceed the minimal inhibitory concentration (MIC) for most Pseudomonas species and a variety of other Gram-negative bacilli recovered from clinical infection. No anterior segment changes that may be attributed to the antibiotic could be demonstrated in the injected eye.
    • Accession Number:
      0 (Anti-Bacterial Agents)
      VZ8RRZ51VK (Tobramycin)
    • Publication Date:
      Date Created: 19760701 Date Completed: 19760823 Latest Revision: 20190704
    • Publication Date:
      20240829
    • Accession Number:
      10.1001/archopht.1976.03910040081015
    • Accession Number:
      938295