Nicotine decreases the activity of glutamate transporter type 3.

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    • Abstract:
      Highlights: [•] Nicotine (0.001–1μM) resulted in a time- and dose-dependent decrease in EAAT3 activity in a Xenopus oocyte expression system. [•] Nicotine decreases EAAT3 activity, but seems to be dependent on PKC and PI3K. [•] Our results may provide an additional mechanism for nicotine-induced seizure. [Copyright &y& Elsevier]
    • Abstract:
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