Cardiovascular risk factors prior to the development of non-insulin-dependent diabetes mellitus in persons with impaired glucose tolerance: the Hoorn Study.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: United States NLM ID: 8801383 Publication Model: Print Cited Medium: Print ISSN: 0895-4356 (Print) Linking ISSN: 08954356 NLM ISO Abbreviation: J Clin Epidemiol Subsets: MEDLINE
    • Publication Information:
      Publication: New York : Elsevier
      Original Publication: Oxford ; New York : Pergamon Press, c1988-
    • Subject Terms:
      Cardiovascular Diseases/*etiology ; Diabetes Mellitus, Type 2/*etiology ; Glucose Intolerance/*complications; Aged ; Blood Glucose/analysis ; Cardiovascular Diseases/blood ; Cholesterol, HDL/blood ; Cross-Sectional Studies ; Female ; Follow-Up Studies ; Glucose Intolerance/blood ; Humans ; Incidence ; Insulin Resistance ; Logistic Models ; Male ; Middle Aged ; Netherlands ; Odds Ratio ; Predictive Value of Tests ; Risk Factors
    • Abstract:
      The aim of the study was to analyze cardiovascular risk factors as predictors for developing non-insulin-dependent diabetes mellitus (NIDDM) in people with impaired glucose tolerance. A cross-sectional survey of glucose tolerance was conducted in people, aged 50-74, who were randomly selected from the registry of the middle-sized town Hoorn (The Netherlands). Based on the mean values of two oral glucose tolerance tests, people were classified in glucose tolerance categories according to the WHO criteria. The mean follow-up time was 36 months (range 13-55 months). The cumulative incidence of NIDDM was 34% (95% CI 16.9-45.1). In multiple logistic regression analysis, cardiovascular risk factors at baseline did not predict the conversion from impaired glucose tolerance to NIDDM, in contrast with the two-hour plasma glucose level (odds ratio 3.56, p < 0.001) and the fasting proinsulin level, as one of the determinants of beta-cell dysfunction (Odds ratio 2.1, p < 0.05). The baseline HDL-cholesterol level, one of the components of the insulin resistance syndrome, was associated with the conversion from impaired glucose tolerance to normal glucose tolerance (Odds ratio 1.58, p < 0.05). The results of our study seem to support the hypothesis that conversion from impaired glucose tolerance to normal glucose tolerance depends on insulin resistance and the development of NIDDM from impaired glucose tolerance depends on beta-cell dysfunction.
    • Accession Number:
      0 (Blood Glucose)
      0 (Cholesterol, HDL)
    • Publication Date:
      Date Created: 19971118 Date Completed: 19971203 Latest Revision: 20190831
    • Publication Date:
      20221213
    • Accession Number:
      10.1016/s0895-4356(97)00119-4
    • Accession Number:
      9363034