CYP2D6-mediated catalysis of tamoxifen aromatic hydroxylation with an NIH shift: similar hydroxylation mechanism in chicken, ra and human liver microsomes.

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    • Abstract:
      Examines tamoxifen metabolism by human P450 forms by synthesizing 4-tritiated-tamoxifen and 4-deuterated-tamoxifen. Key issues of interest; Analysis of pertinent topics and relevant issues; Implications on studies of xenobiotics.