Vbeta-dependent stimulation of bovine and human T cells by host-specific staphylococcal enterotoxins.

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  • Author(s): Deringer JR;Deringer JR; Ely RJ; Monday SR; Stauffacher CV; Bohach GA
  • Source:
    Infection and immunity [Infect Immun] 1997 Oct; Vol. 65 (10), pp. 4048-54.
  • Publication Type:
    Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0246127 Publication Model: Print Cited Medium: Print ISSN: 0019-9567 (Print) Linking ISSN: 00199567 NLM ISO Abbreviation: Infect Immun Subsets: MEDLINE
    • Publication Information:
      Publication: Washington, DC : American Society For Microbiology
      Original Publication: [Bethesda, Md.] American Society for Microbiology.
    • Subject Terms:
      Antigens, Bacterial/*immunology ; Enterotoxins/*immunology ; Lymphocyte Activation/*immunology ; Receptors, Antigen, T-Cell, alpha-beta/*immunology ; Superantigens/*immunology ; T-Lymphocytes/*immunology; Amino Acid Sequence ; Animals ; Cattle ; Enterotoxins/chemistry ; Enterotoxins/genetics ; Humans ; Models, Molecular ; Molecular Sequence Data ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Recombinant Proteins/immunology ; Sequence Analysis, DNA ; Species Specificity
    • Abstract:
      Staphylococcus aureus isolates from bovine and ovine species produce unique molecular variants of type C staphylococcal enterotoxin (SEC). The SEC animal variants have greater than 98% amino acid sequence identity with SEC1, a human-associated SEC. The two SEC animal variants have been designated SEC(bovine) and SEC(ovine) according to their corresponding host species. We showed previously that these toxins induce quantitatively different levels of T-cell stimulation in several animal species. The present study compared the abilities of these closely related host-specific SEC variants to stimulate Vbeta-bearing T cells from bovine and human donors. All three toxins expanded human T cells bearing T-cell receptor Vbeta elements (huVbeta) 3, 12, 13.2, 14, 15, 17, and 20. However, SEC1 resulted in greater expansion of hyVbeta12 than either SEC(bovine) or SEC(ovine). In addition, bovine T cells proliferate in a Vbeta-dependent manner in response to these superantigens (SAgs). All three toxins induced the proliferation of bovine T cells bearing the previously sequenced Vbeta element (boVbeta) from the bovine T-cell clone BTB13 (boVbetaBTB13). SEC1 and SEC(ovine) also were able to induce proliferation of bovine T cells bearing boVbetaBTB35, which SEC(bovine) failed to stimulate. The species-specific differences in T-cell proliferation exhibited by these closely related SEC variants may reflect the evolutionary adaptation of S. aureus, presumably to increase its host range by the manipulation of the immune system in a host-specific manner.
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    • Grant Information:
      AI28401 United States AI NIAID NIH HHS
    • Accession Number:
      0 (Antigens, Bacterial)
      0 (Enterotoxins)
      0 (Receptors, Antigen, T-Cell, alpha-beta)
      0 (Recombinant Proteins)
      0 (Superantigens)
      39424-54-9 (enterotoxin C, staphylococcal)
    • Publication Date:
      Date Created: 19971008 Date Completed: 19971030 Latest Revision: 20210526
    • Publication Date:
      20231215
    • Accession Number:
      PMC175582
    • Accession Number:
      10.1128/iai.65.10.4048-4054.1997
    • Accession Number:
      9317006