Generation of allospecific natural killer cells by stimulation across a polymorphism of HLA-C.

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    • Subject Terms:
      IMMUNE system
    • Abstract:
      Discusses research into the cytotoxicity of human natural killer (NK) cells, which is modulated by the major histocompatibility complex human leukocyte antigen (HLA)-C molecules. Generation of alloreactive NK cells specific for the NK-1 alloantigen in individuals that were homozygous for HLA-C; Results of stimulation of target cells and reciprocal stimulation; Lack of alloreactive NK cells in individuals heterozygous for HLA-C; Conclusions.