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Folly Beach Library
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Edgar Allan Poe/Sullivan's Island Library
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Wando Mount Pleasant Library
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Village Library
9 a.m. - 6 p.m.
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Presence of human papillomaviruses and p16 expression in hypopharyngeal cancer.
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- Author(s): Wendt, Malin; Romanitan, Mircea; Näsman, Anders; Dalianis, Tina; Hammarstedt, Lalle; Marklund, Linda; Ramqvist, Torbjörn; Munck–Wikland, Eva
- Source:
Head & Neck; Jan2014, Vol. 36 Issue 1, p107-112, 6p- Subject Terms:
- Source:
- Additional Information
- Abstract: Background Patients with hypopharyngeal cancer have a 5-year survival of only 15% to 30%. Human papillomavirus (HPV) is a risk factor and a favorable prognostic factor for oropharyngeal carcinoma and p16 has been suggested as a surrogate marker for HPV-induced cancer. However, few studies have been performed on HPV and p16 in hypopharyngeal cancer. Methods One hundred nine pretreatment hypopharyngeal cancer biopsies were analyzed for presence of HPV and p16 overexpression, and the results were correlated to patient survival. Results Of 109 tumors, 7 were HPV-positive (4 HPV16) and 18 overexpressed p16. There was some correlation between survival and HPV status, but not with regard to p16 expression. Notably, all patients with HPV16-positive tumors, also overexpressing p16, lived tumor free for more than 3 years. Conclusion Our results indicate that HPV-induced hypopharyngeal cancer is rare and that p16 is not a suitable biomarker for presence of HPV in this tumor type. © 2013 Wiley Periodicals, Inc. Head Neck 36: 107-112, 2014 [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Head & Neck is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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