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9 a.m. - 5 p.m.
Phone: (843) 766-6635
Wando Mount Pleasant Library
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Village Library
9 a.m. - 1 p.m.
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St. Paul's/Hollywood Library
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Phone: (843) 889-3300
Otranto Road Library
9 a.m. - 5 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. – 5 p.m.
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John's Island Library
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Hurd/St. Andrews Library
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Folly Beach Library
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*open the 2nd and 4th Saturday
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Miss Jane's Building (Edisto Library Temporary Location)
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Nod-like receptors in head and neck squamous cell carcinoma.
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- Author(s): Millrud, Camilla Rydberg (AUTHOR); Kvarnhammar, Anne Månsson (AUTHOR); Tajti, Janos (AUTHOR); Munck-Wikland, Eva (AUTHOR); Uddman, Rolf (AUTHOR); Cardell, Lars Olaf (AUTHOR)
- Source:
Acta Oto-Laryngologica. Dec2013, Vol. 133 Issue 12, p1333-1344. 12p. - Source:
- Additional Information
- Subject Terms: ANALYSIS of variance; CELL culture; CELL lines; ENZYME-linked immunosorbent assay; FLOW cytometry; HEAD tumors; IMMUNOASSAY; IMMUNOHISTOCHEMISTRY; NECK tumors; POLYMERASE chain reaction; RESEARCH funding; SQUAMOUS cell carcinoma; T-test (Statistics); REPEATED measures design; REVERSE transcriptase polymerase chain reaction; DATA analysis software; DESCRIPTIVE statistics; IN vitro studies
- Abstract: Conclusion: The capability of Nod1 to recognize bacteria along with its altered expression and ability to cause an immunological response in head and neck cancer suggest a novel pathway for bacteria to interfere with ongoing cancer inflammation. Objective: Nucleotide oligomerization domain (Nod)-like receptors (NLRs) comprise a recently discovered family of pattern-recognition receptors. In addition to their protective function against infections, accumulating evidence suggests a role for these receptors in various diseases, including cancer. The present study was designed to explore the presence of NLRs in head and neck squamous cell carcinoma, and to determine if these cells have the ability to respond immunologically to ligand stimulation. Methods: The pharyngeal squamous cell carcinoma cell lines Detroit-562 and FaDu were used as a model for head and neck cancer, and compared to healthy primary human nasal epithelial cells. Analyses were performed using immunohistochemistry, real-time RT-PCR, Luminex Multiplex Immunoassay, ELISA, and flow cytometry. Results: The expression profile of NLRs in head and neck cancer cells differed from that seen in healthy epithelial cells. Further, Nod1 stimulation induced an immunological response in tumor cells that differed from the response in normal epithelial cells, especially regarding the expression of β-defensin 2, granulocyte monocyte colony stimulating factor (GM-CSF), granulocyte colony stimulating factor (G-CSF), intercellular adhesion molecule-1 (ICAM-1), and cell survival. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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