[Clonal deletion and clonal anergy as the mechanism of self-tolerance induction].

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  • Author(s): Ota H;Ota H; Yanagida H; Dobashi H; Ishida H
  • Source:
    Nihon rinsho. Japanese journal of clinical medicine [Nihon Rinsho] 1997 Jun; Vol. 55 (6), pp. 1331-6.
  • Publication Type:
    English Abstract; Journal Article; Review
  • Language:
    Japanese
  • Additional Information
    • Source:
      Publisher: Nippon Rinsho Co Country of Publication: Japan NLM ID: 0420546 Publication Model: Print Cited Medium: Print ISSN: 0047-1852 (Print) Linking ISSN: 00471852 NLM ISO Abbreviation: Nihon Rinsho Subsets: MEDLINE
    • Publication Information:
      Original Publication: Osaka : Nippon Rinsho Co
    • Subject Terms:
      Autoimmune Diseases/*etiology ; Clonal Anergy/*immunology ; Clonal Deletion/*immunology ; Immune Tolerance/*immunology ; Self Tolerance/*immunology; Animals ; B-Lymphocytes/immunology ; Humans ; T-Lymphocytes/immunology
    • Abstract:
      In the immune system, it is most important to discriminate self from nonself and to acquire and maintain the unresponsiveness to self antigens, self-tolerance. Recently, the transgenic animals provides the evidence of the mechanism of self-tolerance induction. Self-tolerance is established mainly by elimination, clonal deletion, and functional inactivation, clonal energy, of the autoreactive T cells and B cells. Clonal deletion and clonal anergy are involved not only in the central tolerance, in thymus or bone marrow, but also in the peripheral tolerance. The failure of self-tolerance involves the induction of auto-immune disease.
    • Number of References:
      20
    • Publication Date:
      Date Created: 19970601 Date Completed: 19970905 Latest Revision: 20110727
    • Publication Date:
      20221213
    • Accession Number:
      9200914