Item request has been placed!
×
Item request cannot be made.
×
Processing Request
Neuronal dependency of the glycine transporter GLYT1 expression in glial cells.
Item request has been placed!
×
Item request cannot be made.
×
Processing Request
- Author(s): Zafra F;Zafra F; Poyatos I; Gimenez C
- Source:
Glia [Glia] 1997 Jun; Vol. 20 (2), pp. 155-62.
- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
- Language:
English
- Additional Information
- Source:
Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8806785 Publication Model: Print Cited Medium: Print ISSN: 0894-1491 (Print) Linking ISSN: 08941491 NLM ISO Abbreviation: Glia Subsets: MEDLINE
- Publication Information:
Publication: New York, NY : Wiley-Liss
Original Publication: New York : Alan R. Liss, Inc., c1988-
- Subject Terms:
- Abstract:
Two membrane-localized transporter proteins (GLYT1 and GLYT2) are responsible for removal of extracellular glycine in the mammalian CNS. Whereas GLYT1 seems to be expressed mainly in glial cells, GLYT2 is neuronal. The highest concentrations of both transporters are found in glycinergic areas of the nervous system. The expression of these proteins may be under regulatory control. We demonstrate here that GLYT1 is not expressed in pure glial cultures, but it is expressed by diverse types of glial cells in mixed neuronal/glial cultures. In these mixed cultures, the glial expression of GLYT1 is down-regulated after selective elimination of the neurons. The absence of expression in pure glial cultures and the observed reduction in the GLYT1 expression after neuronal loss support the existence of a regulatory cross-talk between neurons and glia to initiate and sustain the glial expression of GLYT1.
- Accession Number:
0 (Amino Acid Transport Systems, Neutral)
0 (Carrier Proteins)
0 (Glycine Plasma Membrane Transport Proteins)
0 (Slc6a5 protein, rat)
0 (Slc6a9 protein, rat)
SIV03811UC (Kainic Acid)
TE7660XO1C (Glycine)
- Publication Date:
Date Created: 19970601 Date Completed: 19970729 Latest Revision: 20191102
- Publication Date:
20240829
- Accession Number:
10.1002/(sici)1098-1136(199706)20:2<155::aid-glia7>3.0.co;2-8
- Accession Number:
9179600
No Comments.