[The immunobiological properties of trimezon and levamisole on models of humoral and cell-mediated immunogenesis].

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  • Author(s): Liubin GS; Kuz'mitskiĭ BB
  • Source:
    Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 1997 Jan-Feb; Vol. 60 (1), pp. 50-2.
  • Publication Type:
    Comparative Study; English Abstract; Journal Article
  • Language:
    Russian
  • Additional Information
    • Transliterated Title:
      Immunobiologicheskie svoĭstva trimezona i levamizola na modeliakh gumoral'nogo i kletochnooposredovannogo immunogeneza.
    • Source:
      Publisher: Izd-vo Meditsina Country of Publication: Russia (Federation) NLM ID: 9215981 Publication Model: Print Cited Medium: Print ISSN: 0869-2092 (Print) Linking ISSN: 08692092 NLM ISO Abbreviation: Eksp Klin Farmakol Subsets: MEDLINE
    • Publication Information:
      Original Publication: Moskva : Izd-vo Meditsina
    • Subject Terms:
      Adjuvants, Immunologic/*pharmacology ; Antibody Formation/*drug effects ; Aza Compounds/*pharmacology ; Immunity, Cellular/*drug effects ; Levamisole/*pharmacology; Animals ; Dose-Response Relationship, Drug ; Female ; Genotype ; Immunization ; Mice ; Mice, Inbred C57BL ; Mice, Inbred CBA ; Stimulation, Chemical
    • Abstract:
      It was shown in mice experiments that intragastric administration of the low-molecular synthetic immunomodulator of the 8-azasteroid series trimesone increases the immune response of humoral and cell-mediated types to the thymus-dependent antigen, the sheep erythrocytes. The stimulating effect of the drug in vivo is determined by the dose, the antigen load, and the animals' genotype and does not yield to the effect of levamisole or exceeds it in identical experimental conditions.
    • Accession Number:
      0 (Adjuvants, Immunologic)
      0 (Aza Compounds)
      156410-30-9 (trimezon)
      2880D3468G (Levamisole)
    • Publication Date:
      Date Created: 19970101 Date Completed: 19970528 Latest Revision: 20131121
    • Publication Date:
      20240829
    • Accession Number:
      9162286