[Organophosphate-induced myotoxicity].

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  • Author(s): Cavaliere MJ;Cavaliere MJ; Calore EE; Perez NM; Puga FR
  • Source:
    Revista de saude publica [Rev Saude Publica] 1996 Jun; Vol. 30 (3), pp. 267-72.
  • Publication Type:
    Comparative Study; English Abstract; Journal Article
  • Language:
    Portuguese
  • Additional Information
    • Transliterated Title:
      Miotoxicidade por organofosforados.
    • Source:
      Publisher: Universidade De Sao Paulo. Faculdade De Higiene E Saude Publica Country of Publication: Brazil NLM ID: 0135043 Publication Model: Print Cited Medium: Print ISSN: 0034-8910 (Print) Linking ISSN: 00348910 NLM ISO Abbreviation: Rev Saude Publica Subsets: MEDLINE
    • Publication Information:
      Original Publication: Sao Paulo : Universidade De Sao Paulo. Faculdade De Higiene E Saude Publica
    • Subject Terms:
      Cholinesterases/*metabolism ; Diaphragm/*pathology ; Insecticides/*toxicity ; Muscle Fibers, Skeletal/*pathology; Animals ; Atropine/pharmacology ; Cholinesterase Reactivators/pharmacology ; Diaphragm/drug effects ; Female ; Insecticides/antagonists & inhibitors ; Male ; Muscle Fibers, Skeletal/drug effects ; Paraoxon/pharmacology ; Pralidoxime Compounds/pharmacology ; Rats ; Rats, Wistar
    • Abstract:
      Organophosphates comprise a group of chemical compounds extensively used in farming as insecticides, which cause accidental poisoning in animals and men and are also used in suicide attempts. The toxicity of these compounds is due especially to the cardiac and respiratory impairment in consequence of autonomic nervous system disorders. However, it is known that some of these products induce a myopathy in experimental animals and humans. This myopathy is characterized by muscle cell degeneration, involving above all the respiratory muscles. Based on the fact that this involvement certainly enhances the respiratory impairment, this study offers an experimental method for routine evaluation of organophosphate myotoxicity, using a minimal and sufficient battery of stains and histochemical reactions, for muscle necrosis quantification. For this purpose, albino rats (Wistar) treated with the organophosphate paraoxon, were used both with and without antidotes (atropine or pralidoxime). Muscle fiber necrosis in the diaphragm of the rats treated with paraoxon or paraoxon and atropine, that affected about 15% of the fibers in some areas, was detected. In the group treated with paraoxon and pralidoxime, a minimal necrosis was seen, revealing a protective role of this later antidote during the development of myopathy.
    • Accession Number:
      0 (Cholinesterase Reactivators)
      0 (Insecticides)
      0 (Pralidoxime Compounds)
      7C0697DR9I (Atropine)
      EC 3.1.1.8 (Cholinesterases)
      Q9CX8P80JW (Paraoxon)
    • Publication Date:
      Date Created: 19960601 Date Completed: 19970617 Latest Revision: 20190516
    • Publication Date:
      20231215
    • Accession Number:
      10.1590/s0034-89101996000300010
    • Accession Number:
      9110473