[Treatment of elderly patients with hypertension--complications and current drug therapy].

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  • Author(s): Takagawa Y;Takagawa Y; Shimamoto K; Masuda A; Iimura O
  • Source:
    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics [Nihon Ronen Igakkai Zasshi] 1997 Jan; Vol. 34 (1), pp. 30-7.
  • Publication Type:
    Clinical Trial; English Abstract; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • Language:
    Japanese
  • Additional Information
    • Source:
      Publisher: Japan Geriatrics Society Country of Publication: Japan NLM ID: 7507332 Publication Model: Print Cited Medium: Print ISSN: 0300-9173 (Print) Linking ISSN: 03009173 NLM ISO Abbreviation: Nihon Ronen Igakkai Zasshi Subsets: MEDLINE
    • Publication Information:
      Original Publication: Tokyo : Japan Geriatrics Society
    • Subject Terms:
      Adrenergic beta-Antagonists/*therapeutic use ; Angiotensin-Converting Enzyme Inhibitors/*therapeutic use ; Antihypertensive Agents/*therapeutic use ; Calcium Channel Blockers/*therapeutic use ; Diuretics/*therapeutic use ; Hypertension/*complications ; Hypertension/*drug therapy; Age Factors ; Aged ; Cerebrovascular Disorders/complications ; Diabetes Complications ; Drug Utilization ; Humans ; Kidney Diseases/complications ; Myocardial Ischemia/complications
    • Abstract:
      To investigate current drug therapy for elderly hypertensive patients, we performed a case-card study at Sapporo Medical University and its branch hospitals. The case-card was designed to show prescriptions given for hypertension, complications, and blood pressure. In the 2897 valid cases, calcium antagonists were prescribed in 76.3%, followed by beta-blockers (31.4%), angiotensin-converting enzyme inhibitors (ACE-I) (25.1%) and natriuretic diuretics (18.1%). When the patients were divided into an elderly group (> or = 65 y.o., n = 1475), beta-blockers and ACE-I were found to be more frequently used in the non-elderly group, and diuretics were more frequently prescribed in the elderly group. Calcium antagonists were the most frequently used drugs, irrespective of age. As monotherapy drugs, calcium antagonists were chosen most frequently in both groups. Diuretics were the second most frequently used drug in the elderly group, but beta-blockers occupied that position in the younger group and these patients as a whole. In the elderly group, the manner of prescription was analyzed according to major complications. In patients with ischemic heart disease, beta-blockers and diuretics were used more frequently than in patients without that condition. Diuretics were prescribed more frequently in patients with renal dysfunction. Calcium antagonists and ACE-I were used more frequently in the patients with diabetes mellitus. The same differences were found in the non-elderly patients with those complications. However, among patients with stroke, calcium antagonists were more frequently used in the elderly group and ACE-I were performed in the younger patients. In conclusion, calcium antagonists were used very often regardless of age, and the other drugs were used according to age-dependent differences in pathophysiologic mechanism.
    • Accession Number:
      0 (Adrenergic beta-Antagonists)
      0 (Angiotensin-Converting Enzyme Inhibitors)
      0 (Antihypertensive Agents)
      0 (Calcium Channel Blockers)
      0 (Diuretics)
    • Publication Date:
      Date Created: 19970101 Date Completed: 19970516 Latest Revision: 20190831
    • Publication Date:
      20231215
    • Accession Number:
      10.3143/geriatrics.34.30
    • Accession Number:
      9077102