Dirençli Yenidoğan Nöbetlerinde Levetirasetamın Kullanımı. (Turkish)

Levetiracetam for the Treatment of Refractor Neonatal Seizures. (English)

Convulsions are observed commonly in newborns and especially in premature babies. The safety and efficiency of conventional antiepileptic drugs have been extensively investigated. But long term side effects like apoptosis are newly recognized even with the the most commonly used antiepilectic drug, phenobarbital. Much research is related to the safety and efficiency of levetiracetam, one of the recent antiepileptic drugs, used in partial onset idiopathic or generalized seizures of adults and children. However, research on newborns, especially premature newborns is limited. In this paper we present two cases involving seven day newborn premature twins treated with refractory seizures. Seizures were controlled only with levetiracetam therapy. We did not observe any long term side effects which can be related to levetiracetam or seizures in a long term follow up of both patients. [ABSTRACT FROM AUTHOR]

Konvülsiyonlar yenidoğan döneminde, özellikle prematürelerde sık görülür. Konvansiyonel antiepileptiklerin güvenirliliği ve etkinliği ayrıntılı olarak araştırılmıştır. Buna rağmen, en sık kullanılan fenobarbitalin bile daha önce bilinmeyen apopitoz gibi uzun dönem yan etkileri yeni fark edilmektedir. Oysa yeni antiepileptiklerden levetirasetamın çocuk ve erişkinlerin parsiyel başlangıçlı, idiyopatik ya da jeneralize nöbet-lerindeki etkinliği ve güvenirliği ile ilgili birçok çalışma yapılmıştır. Ancakyenidoğanlarda özellikle prematürelerdeki çalışmalar sınırlıdır. Bu yazıda klasik antiepileptiklerere cevap vermeyen, ancak levetirasetamla nöbetleri kontrol altına alınan y [ABSTRACT FROM AUTHOR]

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