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Phone: (843) 722-7550
West Ashley Library
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Folly Beach Library
9 a.m. - 2 p.m.
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Edgar Allan Poe/Sullivan's Island Library
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Wando Mount Pleasant Library
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Phone: (843) 805-6888
Village Library
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Phone: (843) 884-9741
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Lifetime adiposity and risk of pancreatic cancer in the NIH-AARP Diet and Health Study cohort.
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- Author(s): Stolzenberg-Solomon, Rachael Z.; Schairer, Catherine; Moore, Steve; Hollenbeck, Albert; Silverman, Debra T.
- Source:
American Journal of Clinical Nutrition; Oct2013, Vol. 98 Issue 4, p1057-1065, 9p, 5 Charts, 1 Graph- Subject Terms:
SMOKING; ADENOCARCINOMA; ADIPOSE tissues; ANTHROPOMETRY; BODY composition; CONFIDENCE intervals; EPIDEMIOLOGY; EPIDEMIOLOGICAL research; HEALTH behavior; NUTRITIONAL assessment; OBESITY; PANCREATIC tumors; QUESTIONNAIRES; RESEARCH funding; STATISTICAL hypothesis testing; WEIGHT gain; DATA analysis; STATISTICAL significance; BODY mass index; LIFESTYLES; PROPORTIONAL hazards models; PHYSICAL activity; DATA analysis software; DESCRIPTIVE statistics - Source:
- Additional Information
- Subject Terms:
- Abstract: Background: The association of excess body weight across a life-time with pancreatic cancer has not been examined extensively. Objective: We determined the association for body mass index (BMI) at different ages and adiposity duration and gain with incident pancreatic adenocarcinoma in the NIH-AARP Diet and Health Study cohort. Design: Participants aged 50-71 y completed questionnaires at base-line (1995-1996) and 6 months later that queried height and weight history. We calculated HRs and 95% CIs by using Cox proportional hazards models adjusted for age, smoking, sex, and intakes of energy and total fat. Results: Over an average follow-up of 10.5 y, 1206 and 2122 pancreatic cancer cases were identified in the subcohort who completed the second questionnaire (n = 273,975) and the baseline cohort (n = 501,698), respectively. Compared with normal weight, overweight or obesity at ages 18, 35, 50, or >50 y (baseline BMI) was significantly associated with pancreatic cancer, with HRs ranging from 1.15 to 1.53. A longer duration of BMI (in kg/m²) >25.0 was significantly associated with pancreatic cancer (overall HR per 10-y increment of duration: 1.06; 95% CI: 1.02, 1.09), with individuals who reported diabetes having the greatest risk (HR per 10-y increment of duration: 1.18; 95% CI: 1.05, 1.32; P-interaction = 0.01) and rates. A substantial gain in adiposity (>10 kg/m²) after age 50 y was significantly associated with increased pancreatic cancer risk. The etiologic fraction of pancreatic cancer explained by adiposity at any age was 14% overall and 21% in never smokers. Conclusion: Overweight and obesity at any age are associated with increased pancreatic cancer. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of American Journal of Clinical Nutrition is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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