Time course of NT-pro BNP levels after acute ischemic stroke.

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    • Subject Terms:
      NATRIURETIC peptides; BIOMARKERS; ISCHEMIA; STROKE patients; HEART diseases; BLOOD sampling; PATIENTS
    • Abstract:
      Background Studies suggest that N-terminal-pro-brain natriuretic peptide ( NT-pro BNP) can be a biomarker of cardioembolic stroke. However, the best time to measure it after stroke is unknown. We studied the time course of NT-pro BNP in patients with ischemic stroke. Methods Consecutive acute ischemic stroke patients were admitted over 10 months to a Stroke Unit. Stroke type was classified according to TOAST. Blood samples were drawn within 24, 48, and 72 hours after stroke. Friedman test was used to compare NT-pro BNP values across the 3 times in all, cardioembolic and non-cardioembolic stroke patients. Post hoc analysis with Wilcoxon signed-rank tests was conducted with a Bonferroni correction. Mann-Whitney test was used to compare median values of NT-pro BNP between cardioembolic and non-cardioembolic stroke patients. ROC curves were drawn to determine NT-pro BNP accuracy to diagnose cardioembolic stroke at 24, 48, and 72 hours after stroke onset. Results One hundred and one patients were included (29 cardioembolic) with a mean age of 64.5±12.3 years. NT-pro BNP values for cardioembolic stroke were significantly higher ( P < 0.001) than for non-cardioembolic stroke in the 3 time points. NT-pro BNP was highest in the first 24-48 h after ischemic stroke and decreased significantly 72 h after stroke onset. The area under the curve for the three time points was similar. Conclusion NT-pro BNP levels were highest in the first 2 days after ischemic stroke and declined significantly thereafter. However, the area under the curve for the three time points was similar. The first 72 hours after ischemic stroke have a similar diagnostic accuracy to diagnose cardioembolic stroke. [ABSTRACT FROM AUTHOR]
    • Abstract:
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