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Genetic diversity and evolutionary characterization of Chinese porcine reproductive and respiratory syndrome viruses based on NSP2 and ORF5.
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- Author(s): Liu, Jian-Kui; Wei, Chun-Hua; Yang, Xiao-Yan; Hou, Xi-Lin; Dai, AI-Ling; Li, Xiao-Hua; Wei, Mei-Kang; Pan, Xiu-Zhen
- Source:
Archives of Virology; Aug2013, Vol. 158 Issue 8, p1811-1816, 6p, 2 Diagrams, 1 Chart- Subject Terms:
- Source:
- Additional Information
- Subject Terms:
- Abstract: To more fully understand the extent of genetic diversity of PRRSV in China, we analyzed the Nsp2 and ORF5 gene sequences of 35 representative PRRSV isolates from 2008 to 2012. Sequence analysis revealed that the Nsp2 and ORF5 genes have undergone genetic variation. Furthermore, the isolate FJLYDX04 contains five insertions at positions 599 to 603 and is the first isolate from China reported to have an insertion in Nsp2. Our results suggest that the highly pathogenic PRRSV has become the dominant strain in China and that Chinese PRRSV has undergone rapid evolution and can circumvent immune responses induced by currently used vaccines. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Archives of Virology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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