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Phone: (843) 722-7550
West Ashley Library
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Folly Beach Library
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Edgar Allan Poe/Sullivan's Island Library
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Wando Mount Pleasant Library
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Village Library
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Phone: (843) 884-9741
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Association between circulating vitamin K1 and coronary calcium progression in community-dwelling adults: the Multi-Ethnic Study of Atherosclerosis.
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- Author(s): Shea, M. Kyla; Booth, Sarah L.; Miller, Michael E.; Burke, Gregory L.; Haiying Chen; Cushman, Mary; Tracy, Russell P.; Kritchevsky, Stephen B.
- Source:
American Journal of Clinical Nutrition; Jul2013, Vol. 98 Issue 1, p197-208, 12p, 1 Black and White Photograph, 5 Charts- Subject Terms:
ANTIHYPERTENSIVE agents; GERIATRIC nutrition; ANTHROPOMETRY; CHI-squared test; CLINICAL trials; CONFIDENCE intervals; CORONARY disease; DIETARY supplements; EPIDEMIOLOGY; HEALTH behavior; LONGITUDINAL method; NUTRITIONAL assessment; SCIENTIFIC observation; QUESTIONNAIRES; REPLICATION (Experimental design); RESEARCH funding; STATISTICAL sampling; STATISTICS; T-test (Statistics); VITAMIN K; LOGISTIC regression analysis; DATA analysis; MULTIPLE regression analysis; SECONDARY analysis; BODY mass index; LIFESTYLES; RANDOMIZED controlled trials; INDEPENDENT living; DISEASE progression; DATA analysis software; DESCRIPTIVE statistics; NUTRITIONAL status; CALCINOSIS - Source:
- Additional Information
- Subject Terms:
- Abstract: Background: Animal studies have shown that vitamin K treatment reduced vascular calcification, but human data are limited. Objective: We determined the association between vitamin K status and coronary artery calcium (CAC) progression in the Multi-Ethnic Study of Atherosclerosis by using a case-cohort design. Design: Serum phylloquinone (vitamin K1) was measured in 296 participants with extreme CAC progression and 561 randomly selected participants without extreme CAC progression; all subjects had baseline and follow-up CAC measures (mean follow-up: 2.5 y). A serum vitamin K1 concentration was considered low at <1.0 nmol/L (the distribution median). Outcomes were replicated by using post hoc per-protocol analyses of a vitamin Kl supplementation trial. Results: The OR (95% CI) for extreme CAC progression for subjects with low serum vitamin K1 compared with subjects without extreme CAC progression was 1.34 (0.94, 1.90; NS) when adjusted for demographics and confounders. A significant interaction between low vitamin K1 and antihypertension medication use was detected (P = 0.016). Hypertension medication users with low serum vitamin K1 were more likely to have extreme CAC progression than were medication users without extreme CAC progression [OR (95% CI): 2.37 (1.38, 4.09)]. In replication, baseline antihypertensive medication users in the supplementation group had less CAC progression than did those in the control group [adjusted mean ± SEM of the 3-y CAC change was +5 ± 20 Agatston units (AU) in the vitamin K1 group (n = 40) and +44 ± 13 AU in the placebo group (n = 49); P < 0.01]. Conclusions: Although the point estimate of our primary analysis suggests low serum vitamin K1 is associated with greater CAC progression, the difference was NS. Low serum vitamin K1 was significantly associated with CAC progression in antihypertension medication users, which, to our knowledge, is a novel finding conditionally replicated by using an independent sample. Intervention trials are needed to determine whether improving serum vitamin K1 reduces CAC progression, especially in hypertensive individuals. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of American Journal of Clinical Nutrition is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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