Long-term prognosis of infants of diabetic mothers. Relationship between metabolic disorders in newborns and adult offspring.

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  • Author(s): Pribylová H;Pribylová H; Dvoráková L
  • Source:
    Acta diabetologica [Acta Diabetol] 1996 Mar; Vol. 33 (1), pp. 30-4.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9200299 Publication Model: Print Cited Medium: Print ISSN: 0940-5429 (Print) Linking ISSN: 09405429 NLM ISO Abbreviation: Acta Diabetol Subsets: MEDLINE
    • Publication Information:
      Publication: Berlin : Springer Verlag
      Original Publication: Berlin : Springer International, c1991-
    • Subject Terms:
      Diabetes Mellitus, Type 1*/epidemiology ; Diabetes Mellitus, Type 1*/genetics ; Pregnancy in Diabetics*; Diabetes Mellitus, Type 2/*epidemiology ; Glucose Intolerance/*epidemiology ; Infant, Newborn/*physiology ; Metabolic Diseases/*epidemiology; Adult ; Birth Weight ; Blood Pressure ; Body Mass Index ; Female ; Fetal Macrosomia/epidemiology ; Gestational Age ; Glucose Tolerance Test ; Humans ; Hypoglycemia/epidemiology ; Male ; Pregnancy ; Prognosis
    • Abstract:
      The aim of our study was to find out whether the metabolic disorders in the newborns of insulin-dependent diabetic mothers (NDM) in the neonatal adaptation period could be associated with their condition in adulthood. We examined 148 children of diabetic mothers (CDM) aged 20.75 +/- 0.31 years (mean +/- SE); 11 were diabetic patients, while in the remaining 137 CDM, the oral glucose tolerance test (OGTT) was performed. CDM were compared with 31 matched control offspring of healthy mothers. Of the characteristic abnormalities occurring in NDM, the following were present in our study: macrosomia, hypoglycaemia, hyperlactacidaemia, hyperbilirubinaemia. In adulthood, the sum of the blood glucose and plasma insulin values during OGTT, body mass index (BMI) and blood pressure were determined. The observed abnormalities and the degree of their relevance in the neonatal period were not related to the sum of blood glucose and plasma insulin levels, BMI and blood pressure in adulthood, but the values of all these parameters in adulthood were significantly higher in CDM than in controls (P < 0.05-0.001).
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    • Publication Date:
      Date Created: 19960301 Date Completed: 19960916 Latest Revision: 20191101
    • Publication Date:
      20221213
    • Accession Number:
      10.1007/BF00571937
    • Accession Number:
      8777282