Expression of hyaluronidase by tumor cells induces angiogenesis in vivo.

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  • Additional Information
    • Source:
      Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print Cited Medium: Print ISSN: 0027-8424 (Print) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
    • Publication Information:
      Original Publication: Washington, DC : National Academy of Sciences
    • Subject Terms:
      Neovascularization, Pathologic*; Hyaluronoglucosaminidase/*biosynthesis ; Melanoma/*blood supply ; Melanoma/*enzymology; Animals ; Base Sequence ; Cell Division/drug effects ; Chamomile ; Colonic Neoplasms/enzymology ; Cornea ; DNA Primers ; Enzyme Inhibitors/pharmacology ; Female ; Flavonoids/pharmacology ; Glioblastoma/enzymology ; Glioma/enzymology ; Humans ; Hyaluronoglucosaminidase/antagonists & inhibitors ; Melanoma/pathology ; Mice ; Mice, Inbred BALB C ; Molecular Sequence Data ; Neoplasm Invasiveness ; Neoplasm Metastasis ; Oils, Volatile/pharmacology ; Plants, Medicinal ; Polymerase Chain Reaction ; RNA, Messenger/biosynthesis ; Time Factors ; Transcription, Genetic ; Transplantation, Heterologous ; Tumor Cells, Cultured
    • Abstract:
      Hyaluronic acid is a proteoglycan present in the extracellular matrix and is important for the maintenance of tissue architecture. Depolymerization of hyaluronic acid may facilitate tumor invasion. In addition, oligosaccharides of hyaluronic acid have been reported to induce angiogenesis. We report here that a hyaluronidase similar to the one on human sperm is expressed by metastatic human melanoma, colon carcinoma, and glioblastoma cell lines and by tumor biopsies from patients with colorectal carcinomas, but not by tissues from normal colon. Moreover, angiogenesis is induced by hyaluronidase+ tumor cells but not hyaluronidase- tumor cells and can be blocked by an inhibitor of hyaluronidase. Tumor cells thus use hyaluronidase as one of the "molecular saboteurs" to depolymerize hyaluronic acid to facilitate invasion. As a consequence, breakdown products of hyaluronic acid can further promote tumor establishment by inducing angiogenesis. Hyaluronidase on tumor cells may provide a target for anti-neoplastic drugs.
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    • Accession Number:
      0 (DNA Primers)
      0 (Enzyme Inhibitors)
      0 (Flavonoids)
      0 (Oils, Volatile)
      0 (RNA, Messenger)
      EC 3.2.1.35 (Hyaluronoglucosaminidase)
    • Publication Date:
      Date Created: 19960723 Date Completed: 19961029 Latest Revision: 20190501
    • Publication Date:
      20240829
    • Accession Number:
      PMC38834
    • Accession Number:
      10.1073/pnas.93.15.7832
    • Accession Number:
      8755562